The associations of the methylation status of CpGs 1, 2, and 4, and the average SLC6A4 methylation value, with long-term stroke outcomes (composite CCVEs and recurrent stroke) were stronger in patients who experienced SI within 2 weeks of stroke; a significant interaction effect of high CpG 4 methylation status and SI on long-term stroke outcomes was also seen. The gene discussed is SLC6A4; the disease is Stroke.