In this study, we investigated independent and interactive effects of the methylation status of the SLC6A4 gene and suicidal ideation (SI) immediately after stroke (within 2 weeks) on the long-term outcomes (8–14 years) of patients who experienced cerebro-cardiovascular events (CCVEs), including recurrent stroke, myocardial infarction, and vascular death, using data from a longitudinal stroke cohort. This evidence concerns the gene SLC6A4 and stroke disorder.