TGFB1 and synovitis: The aim of this work is therefore to investigate (i) whether VTN(381–397 a.a.) can interact with integrin complexes, (ii) if αVβ6 is expressed in synovitis in OA, (iii) if αVβ6 can activate latent TGF-β1, and (iv) how VTN(381–397 a.a.) can compete with TGF-β1.