ITPR2 and Glucose intolerance: Although no difference between the two genotypes was observed in the regulation of glycaemia during a glucose tolerance test in 20-month-old mice, 26-month-old WT male mice had lost their ability to regulate their glycaemia, whereas KO littermates responded normally to glucose injection (Fig. 1g), suggesting that Itpr2 KO mice were protected from age-induced glucose intolerance.