LPAR1 and pulmonary fibrosis: In vivo, oral administration of AM966 and AM095 reduced lung fibrosis, lung collagen deposition, vascular leakage, and inflammation.240,241 Moreover, AM095 inhibited kidney fibrosis induced by unilateral ureter obstruction and dermal fibrosis induced by bleomycin in murine models.238,240 Both inhibitors antagonize LPA-induced Ca+ release selectively in LPAR1 expressing cells by blocking the binding of guanosine 5′-O-[gamma-thio]triphosphate (GTPγS) to membranes induced by ligation of LPA to LPAR1.238,240,241