ENPP2 and glioblastoma: Treatment of GBM cell line with LPAR1 antagonist, Ki16425, inhibits dramatically migration of these cells in vitro.110,234 Both α-bromomethylene phosphonate, a dual LPA receptor inhibitor/ATX inhibitor, and PF-8380, an ATX inhibitor, delayed in 20 days the growth of GL261 GBM cells injected in the hind limbs of nude mice.252,253