In the functional study, we investigated the biological effect of the FoxM1–STMN1 axis in multiple types of cancer cells using cell counting assay, clone formation assay, soft agar assay and xenograft nude mice model, and we found that the FoxM1–STMN1 axis contributes to cancer cell proliferation and tumor growth in vitro and in vivo. The gene discussed is FOXM1; the disease is cancer.