STMN1 and familial pancreatic carcinoma: Similarly, STMN1 silencing significantly reduces proliferation and induced-apoptosis in response to ruxolitinib.29 It was also reported that siRNA-based inhibition of STMN1 increases the sensitivity of colorectal cancer cells to the treatment of 5-FU.30 Moreover, the inhibition of STMN1 by the anti-cancer potency of three novel indoly-chalcones (CITs) can induce mitotic catastrophe in pancreatic cancer.31