Moreover, the levels of MGL_1304-specific IgE in the sera of AD patients were significantly increased compared to those of the healthy individuals [30], and the activity of histamine release by MGL_1304 and its homolog Mala r 8 from M. restricta were higher than that of Mala s 8 produced by M. sympodialis [31]. Here, IGHE is linked to Alzheimer disease.