Lack of TLR4 and TLR2 responses were shown to affect disseminated candidiasis in mice: lack of TLR4 caused an increased C. albicans kidney burden, while blocking of TLR2 inhibited the production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and IL-1β (171). The gene discussed is TLR2; the disease is disseminated candidiasis.