RUNX1 and leukemia: Among these were RUNX1 (Fig. 4h), MYB (Fig. 4i), and TAL1, 3 out of 8 DE genes (Fisher Exact test, odds ratio = 93, p = 2 × 10−5) that have previously been identified as part of a core transcriptional circuitry important to our leukemia model system [55, 56].