BRD4 and T-cell acute lymphoblastic leukemia: To test GeneWalk on another well-characterized model system, we reanalyzed published NET-seq data [55] describing the response of a human T-cell acute lymphoblastic leukemia (T-ALL) cell line to treatment with JQ1 (Fig. 4a), a small molecule that targets the BET bromodomain in BRD4 and other BET family members [58].