Comparing with our case the three reported cases presented with milder phenotypes (Table 3): case 1 showed oligomenorrhea, ovarian cyst and normal serum 17OHP (basal serum P was not mentioned) [26]; case 2 and 3 showed oligomenorrhea, ovarian cyst, high serum P and 17OHP [23]; the three cases and our case showed different mutations of POR gene. This evidence concerns the gene POR and Ovarian cyst.