The c.1196_1204del mutation in POR gene was firstly reported in two unrelated Turkish PORD patients (HGMD ID:CD117091) and cause a loss of three amino acid p.Pro399_Glu401del (P399_E401del) [11] . This evidence concerns the gene POR and congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency.