SERBP1 and ovarian cancer: Next, we detected SERBP1 protein and mRNA expression in normal ovarian cell lines (IOSE80) and ovarian cancer cell lines (OVCAR3, CAOV3, HO-8910, and SKOV3) and noticed that the protein and mRNA expression of SERBP1 was significantly lower in IOSE80 cells than in all ovarian cancer cells tested (Fig. 3c and d).