MEG8 and non-small cell lung carcinoma: Besides, the expression of MEG8 was also upregulate (P < 0.01) (Fig. 1f), while the expression of miR-15a-5p (P < 0.01) (Fig. 1g) and miR-15b-5p (P < 0.05) (Fig. 1h) was downregulated in the NSCLC cell lines, including A549, H1299, H1975, SPC-A1 and PC-9, compared to that in the human normal pneumonocyte 16HBE cells, further confirming the potential correlation of MEG8 and miR-15a/b-5p with the NSCLC development.