SIRT1 and autosomal dominant Charcot-Marie-Tooth disease type 2K: The drastic reduction of SIRT1 may result from a mitochondrial complex I deficiency, as showed in Charcot-Marie-Tooth disease type 2K [49], or from failed mitochondrial/nuclear crosstalk in the absence of p43 (Additional file 1: Fig. S5) [18].