Nuclear factor, erythroid 2/miR-423-5p axis can induce gluconeogenesis and hyperglycemia through inhibiting the family with sequence similarity 3 member A -adenosine triphosphate (ATP)-serine/threonine kinase Akt pathway, which is involved in the progression of T2D and nonalcoholic fatty liver disease [39]. Here, NFE2 is linked to type 2 diabetes mellitus.