NFAT5 and type 1 diabetes mellitus: Activity enhancement of miR-181a promotes the expression of nuclear factor of activated T cells 5 (NFAT5) while suppresses the induction of forkhead box P3 + Tregs; therefore, miR-181a/NFAT5 axis may provide targets for limiting islet autoimmunity in T1D patients [13, 14].