JAM2 and cancer: Enrichment analysis of DEGs upon aging revealed a negative regulation of hematopoietic or lymphoid organ development (HLOD) marked by the downregulation of Cd34, Plac8, and Foxo3 (Additional file 8: Table S7A), together with a positive regulation of hemostasis with Clu and Selp increased expression, Cell Adhesions Molecule (CAM) genes such as Alcam, Jam2, Major Histocompatibility Complex (MHC) H-2 genes and genes involved in transcriptional miss-regulation in cancer (TMC) (Additional file 8: Table S7B).