TARDBP and amyotrophic lateral sclerosis: In normal conditions, it is located in the nucleus of the cells but in pathological conditions, such as in amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD), TDP-43 is translocated to the cytoplasm where suffers from multiple post-translational modifications including hyperphosphorylation, ubiquitination and truncation that lead to its accumulation [6].