Persistent inflammation that occurs during the pathogenesis of various neurological disorders in the central nervous system is mediated by activation of the NLRP3 inflammasome, a key innate immune sensor that is associated with the progression of several neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury, stroke, depression, and multiple sclerosis [3,4]. Here, NLRP3 is linked to Alzheimer disease.