CASP1 and Parkinson disease: Pre-treatment of MPTP-induced PD mice with tenuigenin for 10 days alleviated motor impairments, increased levels of dopamine and its metabolites in the striatum, reduced the loss of tyrosine hydrolase-positive neuronal cells, and attenuated the expressions of IL-1β, caspase-1, and NLRP3 in the substantia nigra.