The observed increase, in the MKD dataset, in the expression levels of transcripts encoding for proteins that form the erythrocyte spectrin-based membrane skeleton connected to actin, like Solute Carrier Family 4 Member 1 (SLC4A1) and the actin-binding protein dematin, could be a consequence of defective prenylation of Rho and Rac proteins and could perturb the structural integrity of the membrane and hence erythrocyte cell deformability, contributing to anemia. The gene discussed is AKT1; the disease is anemia (phenotype).