DMTN and anemia (phenotype): The observed increase, in the MKD dataset, in the expression levels of transcripts encoding for proteins that form the erythrocyte spectrin-based membrane skeleton connected to actin, like Solute Carrier Family 4 Member 1 (SLC4A1) and the actin-binding protein dematin, could be a consequence of defective prenylation of Rho and Rac proteins and could perturb the structural integrity of the membrane and hence erythrocyte cell deformability, contributing to anemia.