RUNX1 and mevalonic aciduria: This is consistent with our observations in MKD patients where a number of upregulated genes downstream RUNX1 transcription factor (e.g., Arachidonate 12-Lipoxygenase (ALOX12), Myosin regulatory light polypeptide 9, MYL9) are involved in megakaryocyte differentiation, or in platelet activation and aggregation, blood coagulation, and hemostasis, all processes associated to the inflammatory response.