Nevertheless, the exact pathologic classification of GIST is the backbone of GIST treatment and is based on H&E (hematoxylin & eosin) morphology, immunohistochemistry (KIT, DOG1), risk stratification according to Miettinen and molecular testing at least in cases where treatment with TKI is planned [5,20]. This evidence concerns the gene ANO1 and gastrointestinal stromal tumor.