Since an association of the PRNP polymorphisms with classical or atypical scrapie susceptibility and with disease progression in ovine and caprine was established, worldwide, the study of the allele frequencies of the major variants became the main objective to be evaluated [42,43].To date, in the Italian goat populations, SNPs at codons G37V, P42P, T110P, G127S, L133Q, M137I, S138S, I142M, I42T, H143R, R151H, P168Q, T194P, T202T, R211Q, T219T, Q222K, G232G, and S240P were found, but only some of them are associated with known clinical effects [20]. Here, PRNP is linked to scrapie.