On the basis of the studies indicated above, in the present paper, we evaluated the role of Se and PDRN, alone or in association, on NLRP3 inflammasome activation and molecular behavior in order to provide further data in the physiopathology of varicocele to study new triggering molecular mechanisms and possibly identify potential biomarkers and/or medical targets of fertility problems. The gene discussed is NLRP3; the disease is varicocele.