NLRP3 and varicocele: The association of Se plus PDRN markedly reverted the increase in the message of NLRP3, demonstrating a greater effect than that of the two compounds alone (p < 0.0001 versus varicocele rats; p < 0.0001 versus varicocele + Se; p < 0.0001 versus varicocele + PDRN; Figure 1a).