Additionally, in tumor cells, oxidative stress induces the activation of pro-autophagy factors, for instance, BNIP3L, LC3, BNIP3, ATG16L, HIF-1α and nuclear factor kappa B (NF-κB) to promote caveolin-1 (Cav-1) degradation, ultimately resulting in autophagy activation. This evidence concerns the gene HIF1A and neoplasm.