TFEB has been reported to be overexpressed in high-grade gliomas along with the extra genes coding for the autophagy proteins, such as Beclin 1, LC3A, LC3B, Ulk 1, Ulk 2, p62 [60] and sequestome 1 (SQSTM1) [125]. This evidence concerns the gene SQSTM1 and central nervous system cancer.