Contrary to this, other studies showed that dual inhibitor (NVP-BEZ23) of the P13K/mTOR signaling pathway can enhance autophagy through affecting the ATG5 and Beclin1 autophagy-linked proteins and DNA damage repair proteins functions, and can stimulate the radiation sensitive glioblastoma cells [169,170,171]. Here, BECN1 is linked to glioblastoma.