Moreover, chronic obstructive pulmonary disease (COPD) patients show decreased expression of NLRX1, the suppression of which resulted in severe inflammation, alveolar remodeling, increased protease activity, apoptosis and inflammasome activation that have been shown to correlate with disease severity, worse prognosis and reduced quality of life [101]. This evidence concerns the gene NLRX1 and chronic obstructive pulmonary disease.