DAXX-dependent deposition of H3.3 and known relations of the DAXX protein with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins including the α-thalassemia/mental retardation syndrome X-linked protein ATRX [6] make DAXX a main player in chromatin silencing, mainly in the pericentromeric areas [7]. The gene discussed is ATRX; the disease is thalassemia.