STAT3 and prostate carcinoma: Among cucurbitacin derivatives, cucurbitacin-D (CuD) showed an effective inhibitory effect on the proliferation of colon, breast, lung, cervical, and prostate cancer cell lines as a result of Janus kinase/signal transducer activator of transcription 3 (JAK/STAT3) signaling pathway inhibition [15,16,18,19,20].