In addition, GC is also associated with other hereditary cancer syndromes such as Lynch, Li-Fraumeni, familial adenomatous polyposis, Peutz–Jeghers, hereditary breast and ovarian cancer and juvenile polyposis, with mutations in mismatch repair genes, TP53, APC, STK11, BRCA1/2 and SMAD4/BMPR1A, respectively [6]. This evidence concerns the gene APC and Inherited cancer-predisposing syndrome.