CRP and infection: Recent studies have shown that in cases of suspected EOS, when the neonate has no uncertain symptoms and the blood culture is negative at 36–48 h, the discontinuation of empiric antibiotics, guided by the negativity or reduction of the biomarkers of infection (CRP, PCT, and/or PSEP) is a safe practice and saves improperly used antibiotics and costs, with a low rate of suspected re-infections (less than 1%) but no culture-proven bacterial re-infections [5], and above all, without study-related mortality [5,6,7].