UCP1 and hydrops fetalis: Thus, it was shown that supplementation with synthetic fucoxanthin or Undaria pinnatifida-derived fucoxanthin (0.98 mg/g dry weight) at 400 mg/kg body weight in HF-fed rats, increased energy expenditures and β-oxidation, associated with decreasing gene expression involved in adipogenesis such as PPAR-α, peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α), PPAR-γ and UCP1 [49].