However, displacement of bile canalicular transporters to the cytoplasm of hepatocytes was shown in liver biopsies of patients with MVID presenting with cholestasis and homozygous missense mutations p. P660L [37] as well as in patients with MYO5B-PFIC with the homozygous missense mutations p. C266R [11] and p.S158F mutation [15]. This evidence concerns the gene ATP8B1 and microvillus inclusion disease.