RAD54L2 and acute myeloid leukemia: Most importantly, the same group identified the DNA damage repair helicase RAD54L2 and showed that the expression level of ABCC1 and RAD54L2 is associated with etoposide resistance, event-free survival (EFS) and overall survival (OS) in childhood acute myeloid leukemia [132,133], providing evidence that in vitro CRISPR screening hits have direct clinical relevance.