Moreover, Wang et al. studied the cell membrane-tethered urokinase plasminogen activator receptor (uPAR), a gene frequently overexpressed in cancer cells, and demonstrated that its genetic ablation in endocervical and colorectal adenocarcinoma cell lines reduced resistance to 5-FU, cisplatin, docetaxel, and doxorubicin [139]. This evidence concerns the gene PLAUR and colorectal adenocarcinoma.