Obesity is closely related with liver metabolism disorders, such as non-alcoholic fatty liver disease (NAFLD), a hepatic lipid-related metabolic disorder that represents a spectrum of liver derangements starting from benign steatosis that progresses to non-alcoholic steatohepatitis (NASH) characterized by insulin resistance, liver inflammation and fibro-sis [135]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.