The TRPM5 rs886277 polymorphism is a missense (Asn235Ser) variant related to liver fibrosis in HCV-infected patients, primarily as part of the cirrhosis risk score (CRS), which comprised seven SNPs predictive of fibrosis progression in HCV-infected patients [23,24,25,26,27,28] and liver transplantation [29]. Here, TRPM5 is linked to Hepatic fibrosis.