The association found between TRPM5 rs886277 polymorphism and liver fibrosis and cirrhosis was independent of the effect of other SNPs, since logistic regression models were adjusted by the most relevant covariables, including five SNPs previously reported in this cohort (MERTK rs4374383 [37], PNPLA3 rs738409 [38], IL7RA rs6897932 [35], MTHFR rs1801133 [39], and DARC rs12075 [30]). This evidence concerns the gene IL7R and Hepatic fibrosis.