IL1B and obesity due to melanocortin 4 receptor deficiency: In contrast, reduced NLRP12 levels correlate with higher levels of IL-1β in a high-fat diet model of obesity [213], and Silveira et al. observed an increased production of IL-1β and caspase-1 activity in Brucella abortus infected murine BMDM from Nlrp12−/− animals [214].