In contrast, reduced NLRP12 levels correlate with higher levels of IL-1β in a high-fat diet model of obesity [213], and Silveira et al. observed an increased production of IL-1β and caspase-1 activity in Brucella abortus infected murine BMDM from Nlrp12−/− animals [214]. The gene discussed is NLRP12; the disease is obesity due to melanocortin 4 receptor deficiency.