rs16984129 is an SNP loci in the ARMCX5-GPRASP2 gene, which is also known as P60TRP. The protein coded by this gene was initially identified to be downregulated in the temporal lobe of brains in Alzheimer’s disease patients [27] and has been described as a potential target for the development of strategies for inhibiting the early signaling mechanisms involved in neurodegenerative diseases such as AD [28]. This evidence concerns the gene ARMCX5 and early-onset autosomal dominant Alzheimer disease.