To elucidate the biological function of IL-27 during monocytes differentiation under physiologically relevant conditions, two types of MDMs using pooled human AB serum were generated: MDMs induced with AB serum alone were designated “AB-Mac” and MDMs induced with a combination of AB serum and IL-27 were named “ABI-Mac”, and then it was found that ABI-Mac are resistant to HIV infection and possess a significantly enhanced autophagy function [28]. Here, IL27 is linked to HIV infectious disease.