MAP4K2 and asthma: Among the target genes found, there were some relevant genes implicated in asthma pathogenesis, including the nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3), mitogen-activated protein kinase kinase kinase 2 (MAP3K2), dual-specificity phosphatases family (DUSP1, DUSP2, DUSP5 and DUSP16) and nuclear factor kappa β subunit 2 (NFKB2) (Table 2).