In our study, Cx37 and Cx40 displayed inverse appearance, with higher expression of Cx37 in comparison to Cx40 (in wt), while in yotari mice the expression of Cx40 was always higher than in wt, thus implying a regulatory role of Cxs in overcoming high renin expression in yotari. In addition, we also observed decreased Cx37 expression in the P14 yotari medulla that might contribute to hypertension reduction provoked by high renin expression. This evidence concerns the gene REN and hypertensive disorder.