Indeed, Hsp110 expression is reportedly upregulated in various cancers including melanoma, prolactinoma, pituitary adenoma, breast cancer, colorectal cancer, pancreatic cancer, thyroid cancer, esophageal cancer, lung cancer, bladder cancer, islet cell tumor, gastric cancer, lymphoma, seminoma and hepatocellular carcinomas [67,68,69,70,71,72]. The gene discussed is HSPH1; the disease is esophageal cancer.