miR-146a loaded PGA-co-PDL-DOTAP NPs were prepared to resist COPD pathogenesis by targeting interleukin-1 receptor-associated kinase 1 (IRAK1) expression and reducing IL-8 promoter reporter GFP via IL-1β signaling pathway [229]. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.