In 2010, a genome-wide association study by Neale et al. employing 979 advanced AMD cases and 1709 controls found an association between AMD and a variant in the hepatic lipase gene (LIPC), a gene located on chromosome 15q22, in the high-density lipoprotein cholesterol (HDL) pathway [128]. This evidence concerns the gene LIPC and age-related macular degeneration.