MIF and metabolic dysfunction-associated steatohepatitis: In our study using the MCD diet-based NASH model, Mif gene deficiency led to strongly reduced levels of intrahepatic type I NKT cells as evidenced by flow cytometry analysis and lower expression of type I specific Vα14Jα18, indicating that MIF skews NKT cells polarization toward the more pro-inflammatory and pro-fibrotic type I phenotype.