CXCR4 and metabolic dysfunction-associated steatohepatitis: However, interestingly, when we compared the injury-dependent induction of the expression of the MIF receptors Cd74, Cxcr2, and Cxcr4 during toxin-induced liver injury and MCD-induced NASH, we identified a more than 15-fold induction of Cxcr2 selectively in the NASH model, whereas Cxcr4 and Cd74 were only slightly induced in the liver in both models (Figure 5C).