TGFB1 and metabolic dysfunction-associated steatohepatitis: Interestingly, while the reduction of fibrogenesis in globally Mif-deficient mice was quite accurately replicated in MifΔhep mice after MCD diet-induced NASH, intrahepatic mRNA expression levels of the potent HSC-activating cytokine Tgf-β were only decreased in global Mif−/− mice.