In an attempt to find out whether the inability of IL-1R-deficient mice to control GAS or S. aureus infection could be ascribed to the decreased bactericidal activity of IL-1R-deficient mice compared to WT animals, bacteria were mixed with freshly drawn blood from WT or IL-1R-deficient mice and the bacteria were counted at different time points. This evidence concerns the gene IL1R1 and flatulence.