PAI-1 is well recognized to play an important role in the pathogenesis of a wide variety of conditions, including aging, cellular senescence, obesity, cardiovascular disease, hypertension, diabetes, fibrosis and thrombosis [20,56,61,62,63,64,65], It is notable that people with many of these conditions are more susceptible to COVID-19 and have worse outcomes [66]. This evidence concerns the gene SERPINE1 and COVID-19.