A study combining ATAC-seq, RNAseq, and CRISPR screening established that the loss of CHD1 promotes a PCa phenotype of lineage plasticity/chromatin dysregulation and decreased susceptibility to anti-androgens through the dysregulation of the TFs NR3C1, BRN2, NR2F1, and TBX2 [52]. Here, POU3F2 is linked to posterior cortical atrophy.