Two sets of signatures (SIG-HES6 and SIG-DENT) were used to link overlapping hormone signaling (HES6-AR) [80], cell cycle progression (Prolaris) [36], and a molecular subgroup of patients (PCS1) derived by the non-negative matrix factorization (NNMF) of control pathways (SIG-HES) and overlapping DESNT diagnostic signature [81] plus a second NNMF signature PCS3 (SIG-DESNT) to show that aggressive cancer development may be dependent on overlapping common pathways between signatures [43]. The gene discussed is HES6; the disease is cancer.