The knowledge that AR-V7 may contribute to treatment-resistant phenotype emergence has led to clinical studies showing that it is rarely present in primary PCa but is prevalent in CRPC and enriched in patient groups after the administration of ADT (particularly enzalutamide/abiraterone), correlating with a CRPC 59-gene signature that includes HOXB13 [42]. The gene discussed is AR; the disease is posterior cortical atrophy.