Acral melanoma mainly exhibited a variety of “triple wild-type” mechanisms, including point mutations in KIT detected in up to 23% of cases and focal amplifications of KIT, CCND1, CDK4, MDM2, KRAS and PDGFRA. Instead, BRAF and NRAS mutations have been identified in up to 33% and 46%, respectively [17]. The gene discussed is KIT; the disease is melanoma.