The genetic polymorphisms and expression profiles of NLRP3 and related genes have been determined in MDS, AML, ALL and CML, revealing that certain polymorphisms in IL-1β, IL-18, NF-κB or NLRP3 could be potential predictors of these malignant diseases [70,71,72,73]. The gene discussed is IL1B; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.