IL1B and neoplasm: It is well-known that inflammation in the tumor microenvironment is associated with the release of various growth factors and proinflammatory cytokines, such as interleukin-1 (IL-1), IL-4, IL-6, tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β) and IL-10, able to promote tumorigenesis [11,12,13].