TARDBP and amyotrophic lateral sclerosis: Another study also revealed that, while dysregulation of TDP-43 binding miRNAs (i.e., miR-143-5p/3p) may be a common feature of ALS pathology, downregulation of other TDP-43 binding miRNAs (i.e., miR-132-5p/3p and miR-574-5p/3p) was evident in sporadic, TARDBP, Fused In Sarcoma (FUS) and C9orf72, but not superoxide dismutase 1 (SOD1) mutant patients [190].