In contrast to RNA foci and DPRs, other pathologic features of C9orf72 repeat expansion, including TDP-43 and p62 aggregates, are present in glial cells [3,4,5,6] and even in oligodendrocytes [160,161,162] of C9orf72 ALS/FTD cases. Here, TARDBP is linked to amyotrophic lateral sclerosis.