It has been shown that these receptors are affected by C9orf72 mutations [34] because they cause clustering of these receptors, slowing their movement [34], and their intracytoplasmic mislocalization (rather than normal perinuclear localization) in C9orf72 ALS/FTD fibroblasts [47]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.