C9orf72 and amyotrophic lateral sclerosis: Among these, miR-494-3p was identified as the most dysregulated miRNA, and its reduced levels in the C9orf72 astrocytes-secreted extracellular vesicles were correlated with dramatic consequences on axonal/neurite length and motor neuron survival in vitro and in the postmortem ALS corticospinal tract [165].