PDGFRA and gastrointestinal stromal tumor: Platelet-derived growth factor receptor (PDGFR) and its ligand PDGF have been proposed to play an important role in the growth of several cancers.7, 8, 9, 10 Genomic alterations of PDGFB and PDGFRA genes are therefore well documented in dermatofibrosarcoma protuberans (DFSP) and subsets of gastrointestinal stromal tumors (GISTs), with translocation and nonsynonymous mutations as key oncogenic events.