These two receptors have therefore distinct roles in vivo,22 with PDGFRβ being implicated in angiogenesis, whereas PDGFRα is implicated in embryogenesis (development of central nervous system, neural crest and organs).23, 24, 25, 26 It could be speculated that the activation of the PDGFRα may lead to tumor growth, whereas the activation of PDGFRβ may lead to a tumor suppressor activity. This evidence concerns the gene PDGFRA and neoplasm.