Recent results add to evidence of a link between CtBP and cancer progression by showing increased survival in mice models for colon cancer (APCmin/+) (25) and pancreatic adenocarcinoma (CKP) (26) when CtBP2 levels are lowered by CtBP2+/- heterozygosity. Here, CTBP2 is linked to malignant colon neoplasm.