Both CtBP paralogues are global repressors of the epithelial phenotype and of apoptotic pathways (3) by acting as corepressors of genes including tumor suppressive proapoptotic factors (Bik, Noxa), cytoskeletal/cell adhesion molecules (keratin-8, E-cadherin), and cell-cycle inhibitors (4, 10). The gene discussed is CTBP1; the disease is neoplasm.