KCNJ10 and Hypocalciuria: Loss-of-function mutations in the KCNJ10 gene encoding Kir4.1 subunit result in EAST/SeSAME syndrome, a complex electrolyte imbalance disorder manifested as hypotension, natriuresis, hypocalciuria, hypomagnesemia, and hypokalemic metabolic alkalosis (34, 35).