Furthermore, as in rodents, accelerated senescence was confirmed in ADMSCs isolated from patients with CKD as compared to those from healthy kidney donors by the findings of higher expression of DNA damage markers γH2AX and 53BP1 as well as CDKN2A and higher percentage of SA‐β‐gal‐positive cells resulting in the upregulation in SASP genes. This evidence concerns the gene TP53BP1 and chronic kidney disease.